Comprehensive Organic Functional Group Transformations, Volume 1Alan R. Katritzky, Stanley M. Roberts, Otto Meth-Cohn, Charles Wayne Rees This Volume covers the formation of carbon-carbon single-, double- and triple bonds by substitution and addition reactions as well as by various rearrangements. The formation of carbon-carbon multiple bonds by elimination and condensation procedures is fully documented. In addition the synthesis of carbon-hydrogen bonds principally by substitution and addition reactions is featured as is the preparation of a wide variety of carbon-centred anions, cations and radicals. |
Contents
1 | 6 |
| 27 | |
02 | 28 |
11 | 34 |
24 | 41 |
Germanium and Metal Functions | 249 |
and Nucleophiles to CC Multiple Bonds | 293 |
Electrocyclic Additions to CC Multiple Bonds | 319 |
Oxygen Functions | 553 |
or Metal Functions | 589 |
heteroatom Linked Functions Halides Chalcogen or Nitrogen Functions | 673 |
References | 1147 |
| 1317 | |
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Common terms and phrases
a,ẞ-unsaturated acetate addition AIBN alcohols aldehydes alkenes alkenyl alkoxide alkynes allenes allylic amines anion aromatic aryl benzyl bromide Bu"Li C-C bond carbanion carbon atom carbonyl carbonyl compounds catalyst cation chiral chloride cleavage CO₂Et CO₂H CO₂Me CO₂Me complex conjugate cyclisation cycloaddition cyclopropanes deprotonation derivatives diastereoselectivity dienes double bond electrophiles elimination enolate epoxides Equation equiv esters Et2O ether example formation formed Functions give Grignard reagents H₂O halides haloalkanes heteroatom HMPA hydride hydrogen intermediate intramolecular iodide isomer ketones leaving group Lewis acid lithium MeO2C MeOH metal method methyl migration mixture NMe2 nucleophiles occurs oxidation palladium Ph Ph Ph presence propargylic proton R¹ R2 radical react reaction reactive rearrangement reduction reflux regioselectivity ring salts Scheme silyl sodium solvent species stabilised stable stereochemistry stereoselectivity steric substituted substrates sulfones sulfoxide synthesis synthetic temperature tertiary treatment undergo vinyl Wittig reaction ylides Z)-alkenes