Foye's Principles of Medicinal ChemistryThomas L. Lemke, David A. Williams The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Case studies from previous editions and answers to this edition's case studies are available online at thePoint. |
Contents
Historical Perspective of Medicinal Chemistry 1 Chapter 14 Serotonin Receptors and Drugs Affecting | 417 |
Drug Discovery from Natural Products 12 Chapter 15 Amino Acid Neurotransmitters in | 444 |
Drug Design and Relationship of TIMOTHY J MAHER | 462 |
Molecular Modeling and In Silico Drug Chapter 17 Phosphodiesterase Inhibitors | 480 |
Drugs Affecting Central Nervous System | 490 |
Drug Discovery Through Enzyme TIMOTHY J MAHER | 504 |
Pharmaceutical Biotechnology Chapter 20 Antiseizure Agents | 521 |
Medicine 115 | 547 |
Antithrombotics Thrombolytics | 820 |
Drugs Affecting the Hormonal Systems | 855 |
Adrenocorticoids | 877 |
ALI R BANIJAMALI | 913 |
Calcium Homeostasis | 935 |
Antiparasitic Agents | 1084 |
Antifungal Agents | 1112 |
Chapter 41 | 1127 |
Antisense Therapeutic Agents 201 RAYMOND G BOOTH | 601 |
Physicochemical and Biopharmaceutical Drugs of Abuse | 631 |
Chapter 24 Opioid Analgesics | 652 |
An Overview 327 Spasmolytic Agents | 679 |
DRUG RECEPTORS AFFECTING Section 2 Drugs Affecting the Cardiovascular System | 698 |
DAVID J TRIGGLE AHMED S MEHANNA | 722 |
Adrenergic Receptors and Drugs Affecting Inhibitors Antagonists and Calcium | 738 |
Central and Peripheral Sympatholytics | 769 |
Antihyperlipoproteinemics and Inhibitors | 797 |
Cancer and Chemotherapy | 1147 |
Antiviral Agents and Protease | 1193 |
DISEASE STATE MANAGEMENT | 1209 |
Mens Health | 1265 |
WILSON | 1298 |
pKa Values for Some Drugs | 1343 |
Appendix | 1354 |
| 1361 | |
Other editions - View all
Foye's Principles of Medicinal Chemistry Thomas L. Lemke,David A. Williams No preview available - 2008 |
Common terms and phrases
5-HT3 receptors absorption acetylcholine action activity administration affinity agents agonists amine amino acid anesthetic antagonists antidepressants antisense aromatic atoms barbiturates benzodiazepines binding bioavailability biological bond cell CH3 CH3 Chem chemical chemistry clinical compounds conjugation decrease disease dose effects elimination enantiomers enzyme ester excreted factors functional groups G protein-coupled receptors GABA GABAA receptor gene genetic glucuronide half-life hepatic hepatotoxicity hormone human hydrolysis hydroxylation increase inhibition inhibitors interactions intestinal ion channel isoforms ligand lipid liver local anesthetics mechanism membrane metabolites molecular molecule muscarinic neurons neurotransmitter nicotinic norepinephrine oral oxidation pathway patients peptide pharmaceutical pharmacokinetics Pharmacol pharmacological pharmacophore phenobarbital phenytoin plasma concentration potential properties protein protein-coupled reactions reactive receptor residues response result seizures selective sequence serotonin sleep sodium solubility specific structure studies substrate subunit synthesis target therapeutic therapy tion tissue toxicity treatment U.S. FDA urine xenobiotics